Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol
ReviewHumansOther animalsWith adelmidrol (a PEA analogue) with high molecular weight hyaluronic acid, by intra-articular injection
This study tested palmitoylethanolamide together with adelmidrol (a PEA analogue) with high molecular weight hyaluronic acid, by intra-articular injection. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Review
- Subjects
- Not applicable; a narrative review
- Dose used in the study
- 1% hyaluronic acid with 2% adelmidrol by intra-articular injection, as cited
- Duration
- Not stated in the abstract
- What was measured
- What role mast cells and neuroinflammation play in osteoarthritis, and what preclinical and clinical work says about intra-articular adelmidrol.
What the authors reported
This review states:
- PEA levels are reduced in osteoarthritic joints, and adelmidrol, a PEA enhancer, reduced mast cell infiltration, cytokine release and cartilage degeneration in preclinical and clinical studies.
- 1% hyaluronic acid with 2% adelmidrol has been used for knee osteoarthritis with improved analgesia and function.
- No numbers are given.
Limits of this study
A narrative review, not new data, with no numbers in the abstract. The senior author has served as a consultant for Epitech Group SpA, which makes adelmidrol products.
Source
PubMed 36291664 · doi:10.3390/biom12101453
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.