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Sodium chromo-glycate and palmitoylethanolamide: A possible strategy to treat mast cell-induced lung inflammation in COVID-19

Antonio Gigante, Alberto Aquili, Luca Farinelli, Alessandro Caraffa, Gianpaolo Ronconi, Carla Enrica Gallenga, Giulia Tetè, Spyros K Kritas, Pio Conti. Med Hypotheses. 2020;143:109856.

ReviewHumansWith sodium cromoglycate (proposed partner)

This study tested palmitoylethanolamide together with sodium cromoglycate (proposed partner). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.

Design
Review
Subjects
Not stated in the abstract
Dose used in the study
Not stated in the abstract
Duration
Not stated in the abstract
What was measured
Could sodium cromoglycate and palmitoylethanolamide calm mast cell-driven lung inflammation in COVID-19? A hypothesis paper on mast cell activation in SARS-CoV-2 lung inflammation and on both compounds as mast cell modulators.

What the authors reported

Sodium cromoglycate and/or PEA are proposed to suppress mast cell activation and release of pro-inflammatory mediators in the lungs of COVID-19 patients. This is a hypothesis; no patients were studied and no data are reported.

Limits of this study

A hypothesis paper with no experimental or clinical data. It cannot show that either compound works in COVID-19. The authors declare no competing interests.

Source

PubMed 32460208 · doi:10.1016/j.mehy.2020.109856

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.