Effect of an Enteroprotective Complementary Feed on Faecal Markers of Inflammation and Intestinal Microbiota Composition in Weaning Puppies
Controlled trialDogsWith bovine colostrum and Bacillus subtilis (Normalia Extra, Innovet)
This study tested palmitoylethanolamide together with bovine colostrum and Bacillus subtilis (Normalia Extra, Innovet). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Controlled trial
- Subjects
- 29 four-week-old Golden Retriever puppies: 13 control, 16 treated
- Dose used in the study
- A complementary feed of ultramicronised palmitoylethanolamide, bovine colostrum and Bacillus subtilis; amount not stated
- Duration
- 4 weeks
- What was measured
- Average daily gain, faecal score, faecal calprotectin and zonulin, and faecal microbiota composition.
What the authors reported
The trial found:
- No difference in daily gain or faecal score.
- Faecal zonulin and calprotectin were lower in the treated group, most clearly at week 8 (zonulin 42.8 vs 55.3 ng/mL; calprotectin 2.91 vs 5.71 micrograms/g; p < 0.0001 for both).
- Campylobacterota decreased (p = 0.04) and Coprococcus and Pseudomonas increased (p = 0.01 and p = 0.04).
Limits of this study
A small study of 29 puppies from one breed; the abstract does not mention a placebo or blinding. PEA was combined with colostrum and a probiotic, so effects cannot be assigned to PEA. One author is employed by Innovet, which makes the product.
Source
PubMed 37505839 · doi:10.3390/vetsci10070434
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.