Comparison of effectiveness of a food supplement product versus Fosfomycin in the treatment of female recurrent urinary tract infections: Preliminary results of a multicenter comparative observational study
Observational studyHumansWith D-mannose, N-acetylcysteine, Lactobacillus rhamnosus, hibiscus extract
This study tested palmitoylethanolamide together with D-mannose, N-acetylcysteine, Lactobacillus rhamnosus, hibiscus extract. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Observational study
- Subjects
- 89 women with recurrent urinary tract infections: 55 took the supplement, 34 took low-dose fosfomycin
- Dose used in the study
- A five-ingredient supplement for 14 days each month, or fosfomycin every 10 days; PEA amount not in the abstract
- Duration
- 6 months
- What was measured
- UTI episodes at 3 and 6 months, microbiology, quality of life and satisfaction questionnaires, side effects
What the authors reported
UTIs fell in both groups (supplement 1.87 to 0.28 per period; fosfomycin 2.68 to 0.67). Quality of life improved in both. Satisfaction rose with the supplement and fell with the antibiotic. Mild gastrointestinal effects with the supplement; none with fosfomycin.
Limits of this study
Not randomised; the groups differed at baseline (BMI 27 versus 23.5, more infections in the antibiotic group). Five ingredients, so nothing can be assigned to palmitoylethanolamide. Authors declare no conflicts.
Source
PubMed 42479604 · doi:10.1177/03915603261426617
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.