Chronic and neuropathic pain
Published human trials and reviews that measured pain, including nerve-related pain, sciatica, carpal tunnel and low back pain.
This page lists published studies. It reports what the authors did and found, with the limits of each study. It is not advice.
65 studies listed, newest first.
- Palmitoylethanolamide/Baicalin Supplementation and Changes in Pain and Sudomotor Function in Type 2 Diabetes: A Retrospective Matched Real-World Cohort StudyObservational studyHumansWith baicalin
- Temporal effects of Palmitoylethanolamide (PEA) in modulating knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled trialRandomised controlled trialHumans
- Retrospective Evaluation of L-Acetyl Carnitine and Palmitoylethanolamide as Add-On Therapy in Patients with Fibromyalgia and Small Fiber NeuropathyObservational studyHumansWith acetyl-L-carnitine, Boswellia serrata and vitamins B6 and E
- Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populationsReviewHumans
- Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl-L-Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back PainObservational studyHumansWith acetyl-L-carnitine, alpha-lipoic acid, Boswellia serrata, vitamins E and B6
- Mechanisms and clinical applications of palmitoylethanolamide (PEA) in the treatment of neuropathic painReviewHumans
- Evaluation of the Clinical Efficacy of a Novel Palmitoylethanolamide–Equisetum arvense Supplement for the Management of Chronic Pain: Findings from a Prospective Clinical TrialOpen-label, no control groupHumansWith Equisetum arvense (horsetail)
- Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trialRandomised controlled trialHumansWith melatonin
- Palmitoylethanolamide (Levagen+) for acute menstrual pain: a randomized, crossover, double-blind, placebo-controlled trialRandomised controlled trialHumans
- A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative ReviewReviewHumans
- Meta-Analysis of Palmitoylethanolamide in Pain Management: Addressing Literature Gaps and Enhancing UnderstandingMeta-analysisHumans
- Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application ProspectsReviewHumans
- Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants—A Double-Blind Randomised Controlled StudyRandomised controlled trialHumans
- Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain Related to Chronic Inflammatory Demyelinating Polyneuropathy: A Proof-of-Concept StudyOpen-label, no control groupHumans
- Treatment of Established Chemotherapy-Induced Neuropathy with N-Palmitoylethanolamide: A Randomized, Double-Blind Phase II Pilot StudyRandomised controlled trialHumans
- Palmitoylethanolamide and polydatin in pediatric irritable bowel syndrome: A multicentric randomized controlled trialRandomised controlled trialHumansWith polydatin
- Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic NeuropathyRandomised controlled trialHumansWith superoxide dismutase, alpha lipoic acid, B vitamins, vitamin E, magnesium and zinc
- Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent painReviewHumansOther animals
- Extended Treatment with Micron-Size Oral Palmitoylethanolamide (PEA) in Chronic Pain: A Systematic Review and Meta-AnalysisMeta-analysisHumans
- A Fixed Combination of Palmitoylethanolamide and Melatonin (PEATONIDE) for the Management of Pain, Sleep, and Disability in Patients with Fibromyalgia: A Pilot StudyOpen-label, no control groupHumansWith melatonin
- Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled TrialsMeta-analysisHumans
- Alpha-Lipoic Acid, Palmitoylethanolamide, Myrrh, and Oxygen-Ozone Therapy Improve Pharmacological Therapy in Acute Painful Lumbosacral Radiculopathy due to Herniated DiscControlled trialHumansWith alpha-lipoic acid and myrrh
- Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia: results of a randomised controlled studyRandomised controlled trialHumansWith acetyl-L-carnitine
- Orofacial Pain Management: An Overview of the Potential Benefits of Palmitoylethanolamide and Other Natural AgentsReviewHumans
- Oxygen-Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 PatientsObservational studyHumansWith alpha-lipoic acid and myrrh
- The Effect of Palmitoylethanolamide on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers—A Randomized, Double-Blinded, Placebo-Controlled Crossover TrialRandomised controlled trialHumans
- A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic painRandomised controlled trialHumans
- Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical EvidenceMeta-analysisHumans
- Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trialRandomised controlled trialHumansWith baicalin
- Efficacy of a fixed combination of palmitoylethanolamide and acetyl-l-carnitine (PEA+ALC FC) in the treatment of neuropathies secondary to rheumatic diseasesControlled trialHumansWith 82 patients with rheumatoid arthritis or spondyloarthritis and a neuropathy under 12 months old confirmed by electromyography: 42 given the combination on top of standard therapy (18 sciatica, 16 carpal tunnel, 8 lower-limb neuropathy) and 40 matched patients on standard therapy alone (20, 15 and 5)
- Improving Chemotherapy-Induced Peripheral Neuropathy in Patients with Breast or Colon Cancer after End of (Neo)adjuvant Therapy: Results from the Observational Study STEFANOObservational studyHumansWith a patented fatty acid mixture (OnLife)
- ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic PainReviewHumansOther animals
- Measuring the placebo effect in carpal tunnel syndromeRandomised controlled trialHumans
- Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries. A Systematic ReviewReviewHumans
- Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain functionOpen-label, no control groupHumans
- Micronized Palmitoylethanolamide: A Post Hoc Analysis of a Controlled Study in Patients with Low Back Pain – SciaticaRandomised controlled trialHumans
- The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic ReviewReviewHumans
- Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients: a preliminary randomized double-blind controlled trialRandomised controlled trialHumans
- Ultramicronized Palmitoylethanolamide (um-PEA) as Add-on Treatment in Fibromyalgia Syndrome (FMS): Retrospective Observational Study on 407 PatientsObservational studyHumans
- A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritisRandomised controlled trialHumans
- Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide/polydatin on chronic pelvic pain and quality of life in endometriosis patients: An open-label pilot studyOpen-label, no control groupHumansWith polydatin
- Effects of Add-On Ultramicronized N-Palmitol Ethanol Amide in Patients Suffering of Migraine With Aura: A Pilot StudyControlled trialHumans
- Nonsurgical lumbar radiculopathies treated with ultramicronized palmitoylethanolamide (umPEA): A series of 100 casesCase seriesHumans
- Ultra-micronized Palmitoylethanolamide Effects on Sleep-wake Rhythm and Neuropathic Pain Phenotypes in Patients with Carpal Tunnel Syndrome: An Open-label, Randomized Controlled StudyControlled trialHumans
- Efficacy of Palmitoylethanolamide for Pain: A Meta-AnalysisMeta-analysisHumans
- Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndromeRandomised controlled trialHumansWith polydatin
- Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized studyRandomised controlled trialHumans
- N-of-1 Randomized Trials of Ultra-Micronized Palmitoylethanolamide in Older Patients with Chronic PainRandomised controlled trialHumans
- The efficacy of an association of palmitoylethanolamide and alpha-lipoic acid in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized clinical trialRandomised controlled trialHumansWith alpha-lipoic acid
- The beneficial use of ultramicronized palmitoylethanolamide as add-on therapy to Tapentadol in the treatment of low back pain: a pilot study comparing prospective and retrospective observational armsObservational studyHumans
- Ultramicronized palmitoylethanolamide in spinal cord injury neuropathic pain: A randomized, double-blind, placebo-controlled trialRandomised controlled trialHumans
- Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacyReviewHumans
- Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing–Remitting Multiple SclerosisRandomised controlled trialHumans
- Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysisMeta-analysisHumans
- Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational StudiesObservational studyHumans
- Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndromeReviewHumans
- Sex differences in N-palmitoylethanolamide effectiveness in neuropathic pain associated with lumbosciatalgiaControlled trialHumans
- Effects of two different specific neck exercise interventions on palmitoylethanolamide and stearoylethanolamide concentrations in the interstitium of the trapezius muscle in women with chronic neck shoulder painRandomised controlled trialHumans
- Micronized Palmitoylethanolamide Reduces the Symptoms of Neuropathic Pain in Diabetic PatientsOpen-label, no control groupHumans
- Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different EtiopathogenesisObservational studyHumans
- Palmitoylethanolamide Versus a Nonsteroidal Anti-Inflammatory Drug in the Treatment of Temporomandibular Joint Inflammatory PainRandomised controlled trialHumans
- Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wristControlled trialHumans
- Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathyOpen-label, no control groupHumans
- Palmitoylethanolamide (Normast) in chronic neuropathic pain by compressive type lumbosciatalgia: multicentric clinical studyRandomised controlled trialHumans
- Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observationsCase seriesHumansWith polydatin