Altered relationship between anandamide and glutamate in circulation after 30 min of arm cycling: A comparison of chronic pain subject with healthy controls
Controlled trialHumans
- Design
- Controlled trial
- Subjects
- 21 people with chronic neck pain and 11 healthy controls
- Dose used in the study
- No palmitoylethanolamide was given; endogenous plasma levels were measured
- Duration
- A single 30-minute session of arm cycling
- What was measured
- Pain ratings and plasma levels of anandamide, 2-arachidonoylglycerol, oleoylethanolamide, palmitoylethanolamide, stearoylethanolamide and glutamate before and after exercise.
What the authors reported
This controlled trial found:
- Pain intensity differed between groups before and after exercise.
- After exercise anandamide fell in healthy controls but not in the chronic pain group.
- Anandamide and glutamate correlated strongly in controls after exercise but not in the pain group.
- The glutamate to anandamide ratio rose in controls.
- No specific change in palmitoylethanolamide was reported.
Limits of this study
A small measurement study; no PEA was given. Palmitoylethanolamide was one of several lipids assayed and the abstract reports no finding specific to it. Funding and conflicts not stated in the abstract.
Source
PubMed 31838922 · doi:10.1177/1744806919898360
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.