Ultra-micronized Palmitoylethanolamide Effects on Sleep-wake Rhythm and Neuropathic Pain Phenotypes in Patients with Carpal Tunnel Syndrome: An Open-label, Randomized Controlled Study
Controlled trialHumans
- Design
- Controlled trial
- Subjects
- 42 patients awaiting carpal tunnel surgery, with sleep disturbance and pain, randomised to two groups
- Dose used in the study
- 600 mg of ultramicronised palmitoylethanolamide twice a day, before and after surgery. The comparison group had surgery only.
- Duration
- The period before and after surgery
- What was measured
- Sleep quality on the Pittsburgh Sleep Quality Index as the main outcome, and pain on a numeric rating scale
What the authors reported
Sleep quality and pain both improved significantly in the treated group by the end of the pre-surgery period (p < 0.0001 for each), results the authors describe as preliminary.
Limits of this study
Open-label, with no placebo. The comparison group received nothing, so patients knew whether they were treated, and both outcomes were self-reported. The blinded trial by Faig-Martí 2017 in the same condition found no advantage over placebo. The entry was checked against the abstract only. Funding was not listed.
Source
doi:10.2174/1871527317666180420143830
Entry checked against the abstract and citation held by Crossref, the DOI registry on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.