Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia
Controlled trialHumans
- Design
- Controlled trial
- Subjects
- 37 women with fibromyalgia and 33 healthy controls
- Dose used in the study
- No palmitoylethanolamide was given; plasma levels were measured before and after a resistance exercise programme
- Duration
- 15 weeks
- What was measured
- Plasma anandamide, 2-AG, oleoylethanolamide, palmitoylethanolamide and stearoylethanolamide, alongside pain, depression, anxiety, fatigue and muscle strength.
What the authors reported
This controlled trial found:
- After 15 weeks of resistance exercise, anandamide rose and SEA fell in the fibromyalgia group.
- Pain intensity and depression scores fell and muscle strength rose, with strength linked to 2-AG.
- The abstract reports no PEA-specific result.
- No associations between pain, depression and lipid level changes were assured.
Limits of this study
An exercise study in 37 women with fibromyalgia and 33 healthy controls; PEA was measured, not given, and the abstract gives no PEA result. Funding and conflicts not stated in the abstract.
Source
PubMed 32168104 · doi:10.1249/MSS.0000000000002293
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.