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ENDOCANNABINOIDS RECEPTORS MEDIATED CENTRAL AND PERIPHERAL EFFECTS (REVIEW)

M Ghonghadze, K Pachkoria, M Okujava, N Antelava, N Gongadze. Georgian Med News. 2020;(298):137-143.

ReviewHumansOther animals

Design
Review
Subjects
Not stated in the abstract
Dose used in the study
Not stated in the abstract
Duration
Not stated in the abstract
What was measured
What endocannabinoid receptors do in the body: a narrative review of their distribution, signalling pathways, and roles in pain, cognition, feeding, fertility and psychiatric disorders.

What the authors reported

Anandamide, 2-AG and palmitoylethanolamide are described as endocannabinoids, with PEA proposed to bind a 'CB2-like' receptor; the authors summarise CB1 and CB2 distribution and signalling, analgesic actions involving PPAR-alpha, TRPV receptors and COX-2, and possible roles in memory, Alzheimer's disease, schizophrenia and depression. No numbers are given.

Limits of this study

A narrative review in a regional journal, not a trial. Some statements (for example PEA acting through CB2-like receptors) reflect the authors' framing. No DOI. Funding and conflicts not stated in the abstract.

Source

PubMed 32141867

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.