Non-drug pain relievers active on non-opioid pain mechanisms
ReviewHumansOther animals
- Design
- Review
- Subjects
- Not stated in the abstract
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Which non-drug substances, including palmitoylethanolamide, have preclinical and clinical evidence for chronic postoperative pain and chronic back pain: B vitamins, vitamin C, vitamin D, alpha lipoic acid, N-acetylcysteine, acetyl L-carnitine, curcumin, Boswellia serrata, magnesium and coenzyme Q10.
What the authors reported
Preclinical and clinical findings together suggest these compounds deserve closer attention, and combinations of a few act on many pain pathways, the authors say. They name vitamin B complex plus gabapentin, vitamin B complex plus diclofenac, and alpha lipoic acid for burning mouth syndrome as examples with clinical support, and say all of these need controlled independent clinical studies. No PEA-specific results are given in the abstract.
Limits of this study
A narrative review, not a systematic review or meta-analysis. The abstract gives no numbers and no PEA-specific findings. Funding and conflicts not stated in the abstract.
Source
PubMed 34498362 · doi:10.1111/papr.13073
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.