Therapeutic Potential of Diacerein in Management of Pain
ReviewHumansOther animals
- Design
- Review
- Subjects
- Not applicable; a narrative review
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- How diacerein and rhein act on pain: their effects on mediators involved in neuropathic, inflammatory and nociceptive pain, including TRPV1, substance P, cytokines, histamine, palmitoylethanolamide, NF-kB and prostaglandins
What the authors reported
The review discusses the effect of diacerein and rhein on pain mediators, including palmitoylethanolamide, and says the data highlight a role for diacerein in neuropathic, nociceptive and inflammatory pain. The authors say clinical trials and mechanism studies are still needed. No PEA-specific data are given in the abstract.
Limits of this study
A narrative review of another drug; PEA is mentioned only as a mediator. Funding and conflicts not stated in the abstract.
Source
PubMed 36281831 · doi:10.2174/2589977514666220428124623
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.