Effect of intravenous, perioperative-administered lidocaine on serum levels of endocannabinoids and related N-acylethanolamines in children
Controlled trialHumans
- Design
- Controlled trial
- Subjects
- 44 children having extensive spinal surgery (23 given intravenous lidocaine, 21 not) and 23 healthy matched children
- Dose used in the study
- No palmitoylethanolamide was given; intravenous lidocaine as a co-analgesic during anaesthesia
- Duration
- Blood sampled before surgery, immediately after, at 6 hours and the next morning
- What was measured
- Serum anandamide, 2-arachidonoylglycerol, palmitoylethanolamide and oleoylethanolamide by liquid chromatography-mass spectrometry, in 44 children undergoing spinal surgery (23 given lidocaine, 21 not) and 23 healthy controls.
What the authors reported
Levels were similar in controls and patients before surgery. After surgery the lidocaine group had higher anandamide and lower 2-AG than the non-lidocaine group. Palmitoylethanolamide peaked in the lidocaine group 6 hours after surgery and was higher than in the non-lidocaine group at that time (P=0.0003).
Limits of this study
A measurement study of endogenous levels in children; no PEA was given. Allocation to lidocaine is not described as randomised in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 31630508 · doi:10.23736/S0375-9393.19.13703-0
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.