Sense of smell
Published human studies that measured the sense of smell, mostly after COVID-19. Most tested palmitoylethanolamide combined with luteolin.
This page lists published studies. It reports what the authors did and found, with the limits of each study. It is not advice.
14 studies listed, newest first.
- Persistent COVID-19 parosmia and olfactory loss post olfactory training: randomized clinical trial comparing central and peripheral-acting therapeuticsRandomised controlled trialHumansWith luteolin; alpha-lipoic acid in two arms
- Palmitoylethanolamide and Luteolin for Postinfectious Olfactory Disorders: How Clinically Meaningful Is Its Effect?Randomised controlled trialHumansWith luteolin
- Infectious disease for the rhinologistReviewHumansWith luteolin (ultramicronised palmitoylethanolamide with luteolin, as discussed in the review)
- Efficacy of Palmitoylethanolamide and Luteolin Association on Post-Covid Olfactory Dysfunction: A Systematic Review and Meta-Analysis of Clinical StudiesMeta-analysisHumansWith luteolin
- Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trialRandomised controlled trialHumansWith luteolin
- Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)?Observational studyHumansWith luteolin (co-ultramicronised PEA-LUT), with olfactory training
- Parosmia COVID-19 Related Treated by a Combination of Olfactory Training and Ultramicronized PEA-LUT: A Prospective Randomized Controlled TrialRandomised controlled trialHumansWith luteolin (co-ultramicronised PEA-LUT), with olfactory training
- Effect of any form of steroids in comparison with that of other medications on the duration of olfactory dysfunction in patients with COVID-19: A systematic review of randomized trials and quasi-experimental studiesReviewHumansWith luteolin (palmitoylethanolamide and luteolin was one of the comparators reviewed)
- Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal StudyOpen-label, no control groupHumansWith luteolin
- Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo-Controlled Clinical TrialRandomised controlled trialHumansWith luteolin
- Investigational drugs for the treatment of olfactory dysfunctionReviewHumans
- Interventions for the treatment of persistent post-COVID-19 olfactory dysfunctionReviewHumansWith luteolin (in the included trial)
- Interventions for Improving Long COVID-19 Symptomatology: A Systematic ReviewReviewHumansWith luteolin, with olfactory rehabilitation (in the included trial)
- Randomized clinical trial "olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin": preliminary resultsRandomised controlled trialHumansWith luteolin