Safety in human trials
Published reviews and trials that report adverse events and tolerability in people.
This page lists published studies. It reports what the authors did and found, with the limits of each study. It is not advice.
19 studies listed, newest first.
- Investigating Properties of Palmitoylethanolamide in Physiology and Disease: Far Beyond an Anti-Inflammatory ShieldReviewHumansOther animals
- Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populationsReviewHumans
- Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application ProspectsReviewHumans
- Effect of Palmitoylethanolamide Compared to a Placebo on the Gut Microbiome and Biochemistry in an Overweight Adult Population: A Randomised, Placebo Controlled, Double-Blind StudyRandomised controlled trialHumans
- Extended Treatment with Micron-Size Oral Palmitoylethanolamide (PEA) in Chronic Pain: A Systematic Review and Meta-AnalysisMeta-analysisHumans
- Palmitoylethanolamide: A Potential Alternative to CannabidiolReviewHumans
- Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled TrialsMeta-analysisHumans
- In Vitro and In Vivo Safety of Hyaluronic Acid-Decorated Microparticles for Intravitreal Injection of Palmitoylethanolamide, Citicoline, or Glial-Cell-Derived Neurotrophic FactorLaboratory studyHumansOther animals
- Herbal Cannabis Use Is Not Associated with Changes in Levels of Endocannabinoids and Metabolic Profile Alterations among Older AdultsOpen-label, no control groupHumans
- Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical EvidenceMeta-analysisHumans
- Long-term and serious harms of medical cannabis and cannabinoids for chronic pain: a systematic review of non-randomised studiesMeta-analysisHumans
- Palmitoylethanolamide: A Natural Compound for Health ManagementReviewHumansOther animals
- Tolerability profile of topical cannabidiol and palmitoylethanolamide: a compilation of single-centre randomized evaluator-blinded clinical and in vitro studies in normal skinControlled trialHumansTopicalWith cannabidiol
- The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept studyRandomised controlled trialHumansWith JNJ-42165279 (a FAAH inhibitor that raises endogenous PEA, anandamide and OEA, tested alone)
- Tolerability of Palmitoylethanolamide in a Pediatric Population Suffering from Migraine: A Pilot StudyOpen-label, no control groupHumans
- Dietary interventions for multiple sclerosis-related outcomesMeta-analysisHumans
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP3652, a Reversible Fatty Acid Amide Hydrolase Inhibitor, in Healthy, Nonelderly, Japanese Men and Elderly, Japanese Men and Women: A Randomized, Double-blind, Placebo-controlled, Single and Multiple Oral Dose, Phase I StudyRandomised controlled trialHumansWith ASP3652 (a FAAH inhibitor that raises endogenous PEA, tested alone)
- Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacyReviewHumans
- Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potentialLaboratory studyHumansOther animals