The Basal Pharmacology of Palmitoylethanolamide
ReviewHumansOther animals
- Design
- Review
- What was measured
- How palmitoylethanolamide is made, broken down, absorbed and distributed in the body, and what its proposed molecular targets are
What the authors reported
PPAR-alpha is described as the best supported target, with further evidence for TRPV1 and GPR55 and for effects on mast cells. Oral palmitoylethanolamide did not significantly change plasma anandamide in humans or dogs. Bioavailability, tissue distribution and the route and rate of elimination are stated as not known, and most clinical studies are described as small.
Limits of this study
A narrative review, not a systematic one. Most of the mechanism evidence it covers comes from cells and laboratory animals, and the authors note that almost all of the animal studies used males only.
Source
Entry checked against the full text at the publisher (MDPI) on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.