Role of PPAR-Allopregnanolone Signaling in Behavioral and Inflammatory Gut-Brain Axis Communications
ReviewHumansOther animals
- Design
- Review
- Subjects
- Not applicable; a narrative review
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- How PPAR-alpha and the neurosteroid allopregnanolone link the gut microbiome, inflammation and mood
What the authors reported
Stress and obesogenic diets are proposed to suppress PPAR-alpha in brain, gut, fat and immune cells, favouring inflammation and mood instability, while micronutrients and modulators of PPAR-alpha function are said to improve microbiome composition, systemic inflammation, anxiety and depression, and PPAR activation ameliorated depressive-like behaviour and fear responses in rodent stress models. Palmitoylethanolamide is named only as one of the endocannabinoids and congeners through which PPAR-alpha regulates metabolic and inflammatory processes. PPAR-alpha and allopregnanolone in the colon are put forward as mediators of gut-brain communication.
Limits of this study
A narrative review and hypothesis paper, not new data. Much of the cited evidence is from rodent models. Funding and conflicts not stated in the abstract.
Source
PubMed 37156350 · doi:10.1016/j.biopsych.2023.04.025
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.