Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis

Anne Lise Ferrara, Fabiana Piscitelli, Angelica Petraroli, Roberta Parente, Maria Rosaria Galdiero, Gilda Varricchi, Giancarlo Marone, Massimo Triggiani, Vincenzo Di Marzo, Stefania Loffredo. J Immunol Res. 2019 Jul 1:2019:5836476.

Observational studyHumans

Design

Observational study

Subjects

23 patients with mastocytosis and 23 healthy people

Dose used in the study

No palmitoylethanolamide was given; plasma levels were measured

Duration

Cross-sectional

What was measured

Plasma PLA2 and PLC activity, diacylglycerols, 2-AG, anandamide, palmitoylethanolamide and oleoylethanolamide; relation to symptoms, severity and tryptase.

What the authors reported

The study found:

• PLA2 and PLC activity and two diacylglycerols were higher in mastocytosis; 2-AG was unchanged.
• Anandamide was lower and palmitoylethanolamide higher in patients than controls.
• Enzyme activity was raised only in patients with mediator-related symptoms.
• PLC activity correlated with severity and tryptase, and anandamide correlated negatively with tryptase.

Limits of this study

A small cross-sectional measurement study; no PEA was given and it cannot show cause. Funding and conflicts not stated in the abstract.

Source

PubMed 31355297 · doi:10.1155/2019/5836476

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.