The Role of PPAR Alpha in the Modulation of Innate Immunity
ReviewHumansOther animals
- Design
- Review
- Subjects
- Not stated in the abstract
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- How PPAR-alpha shapes innate immunity: its interplay with inflammatory transcription factors, pattern-recognition receptors and the endocannabinoid system, and its functions in infection, phagocytosis, macrophages, innate lymphoid cells and mast cells.
What the authors reported
PPAR-alpha suppresses inflammatory reactions and modulates innate immune cells, with examples from parasitic, bacterial and viral infections, the authors summarise. They conclude the evidence supports applying endogenous and pharmacological PPAR-alpha agonists to immune-related disorders.
Limits of this study
A narrative review with no new data; the abstract does not name palmitoylethanolamide, though PEA is a PPAR-alpha agonist. The authors declare no conflict of interest.
Source
PubMed 34638886 · doi:10.3390/ijms221910545
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.