Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids-A PREVIEW Study
Controlled trialHumans
- Design
- Controlled trial
- Subjects
- 38 overweight adults (mean age 64.5, BMI 28.9) about 34 months after weight loss; high-protein diet n=20, moderate-protein n=18
- Dose used in the study
- No palmitoylethanolamide was given; plasma PEA was measured during 48 hours in a respiration chamber on a high-protein or moderate-protein diet
- Duration
- 48 hours
- What was measured
- Blood pressure, serum lipoproteins, flow-mediated dilation, pulse wave measures, retinal vessel calibres, 24-hour ambulatory blood pressure, and plasma anandamide, 2-AG, OEA, PEA and pregnenolone.
What the authors reported
This controlled trial found:
- Blood pressure, lipoproteins and vascular function did not differ between diet groups.
- Only heart rate was higher on the high-protein diet, and it was positively associated with OEA.
- OEA and PEA were positively associated with total and LDL cholesterol.
- Vascular markers were not associated with the endocannabinoid-type lipids.
Limits of this study
A short 48-hour comparison in 38 people; PEA was an observed blood marker, not a treatment. The associations do not show cause. The authors declare no conflicts and state the funders had no role.
Source
PubMed 32455987 · doi:10.3390/nu12051512
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.