Palmitoylethanolamide supplementation partly modulates eccentric exercise-induced changes in the bioactive lipid profile of skeletal muscle tissue
Randomised controlled trialHumans
- Design
- Randomised controlled trial
- Subjects
- 10 healthy men, double-blind crossover
- Dose used in the study
- Levagen+ 2 x 350 mg a day or maltodextrin placebo
- Duration
- Each condition covered one bout of muscle-damaging exercise (240 eccentric knee-extensor contractions) with biopsies at baseline and 48 hours
- What was measured
- Bioactive lipid mediators in muscle biopsies by LC-MS/MS lipidomics
What the authors reported
Many lipid mediators derived from arachidonic, docosahexaenoic, linoleic and alpha-linolenic acids fell 48 hours after exercise on placebo but stayed level or rose on PEA. MCTR3 was higher and LXB4 and AT-RvD3 lower on PEA regardless of exercise.
Limits of this study
10 participants. Mechanistic outcome (muscle lipid profile), not soreness or performance. Abstract only; funding and product supply not stated in the text supplied. Same group as the 2024 Schouten trial.
Source
doi:10.1007/s00424-026-03208-6
Entry checked against the abstract, supplied by Devlin on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.