Chronic and neuropathic pain
Published human trials and reviews that measured pain, including nerve-related pain, sciatica, carpal tunnel and low back pain.
This page lists published studies. It reports what the authors did and found, with the limits of each study. It is not advice.
112 studies listed, newest first.
- Palmitoylethanolamide (PEA) in the treatment of restless legs syndrome: Rationale and case reportCase seriesHumans
- Phospholipid-Based Delivery System Optimizes the Solubility and Systemic Exposure of Palmitoylethanolamide and Supports Clinical Benefits in Chronic Neuropathic Low Back PainRandomised controlled trialHumans
- Efficacy, safety, and tolerability of palmitoylethanolamide in the management of diabetic neuropathic pain: a systematic review and meta-analysisMeta-analysisHumans
- Water-Dispersible Palmitoylethanolamide (PEA) Supplementation for Functional Improvement in Adults With Chronic Sciatica-Related Back Pain: A Pilot Clinical TrialOpen-label, no control groupHumansWith Acmella oleracea extract
- Palmitoylethanolamide/Baicalin Supplementation and Changes in Pain and Sudomotor Function in Type 2 Diabetes: A Retrospective Matched Real-World Cohort StudyObservational studyHumansWith baicalin
- Temporal effects of Palmitoylethanolamide (PEA) in modulating knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled trialRandomised controlled trialHumans
- Retrospective Evaluation of L-Acetyl Carnitine and Palmitoylethanolamide as Add-On Therapy in Patients with Fibromyalgia and Small Fiber NeuropathyObservational studyHumansWith acetyl-L-carnitine, Boswellia serrata and vitamins B6 and E
- Effective Management of Chronic Low Back Pain in the Elderly: A One-Year Cohort Study of Oxygen-Ozone Therapy Under CT Guidance Combined with Alpha Lipoic Acid, Palmitoylethanolamide, and MyrrhObservational studyHumansWith alpha-lipoic acid and myrrh, alongside CT-guided oxygen-ozone paravertebral injections
- Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populationsReviewHumans
- Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl-L-Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back PainObservational studyHumansWith acetyl-L-carnitine, alpha-lipoic acid, Boswellia serrata, vitamins E and B6
- Mechanisms and clinical applications of palmitoylethanolamide (PEA) in the treatment of neuropathic painReviewHumans
- Palmitoylethanolamide: A Multifunctional Molecule for Neuroprotection, Chronic Pain, and Immune ModulationReviewHumansOther animals
- Evaluation of the Clinical Efficacy of a Novel Palmitoylethanolamide–Equisetum arvense Supplement for the Management of Chronic Pain: Findings from a Prospective Clinical TrialOpen-label, no control groupHumansWith Equisetum arvense (horsetail)
- Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trialRandomised controlled trialHumansWith melatonin
- Palmitoylethanolamide (Levagen+) for acute menstrual pain: a randomized, crossover, double-blind, placebo-controlled trialRandomised controlled trialHumans
- A Decades-Long Journey of Palmitoylethanolamide (PEA) for Chronic Neuropathic Pain Management: A Comprehensive Narrative ReviewReviewHumans
- Meta-Analysis of Palmitoylethanolamide in Pain Management: Addressing Literature Gaps and Enhancing UnderstandingMeta-analysisHumans
- Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application ProspectsReviewHumans
- Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy StudyObservational studyHumans
- Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants—A Double-Blind Randomised Controlled StudyRandomised controlled trialHumans
- Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain Related to Chronic Inflammatory Demyelinating Polyneuropathy: A Proof-of-Concept StudyOpen-label, no control groupHumans
- Efficacy of mast cell directed therapies in irritable bowel syndrome: a systematic reviewReviewHumansWith polydatin (palmitoylethanolamide-polydatin was one of the therapies reviewed)
- Treatment of Established Chemotherapy-Induced Neuropathy with N-Palmitoylethanolamide: A Randomized, Double-Blind Phase II Pilot StudyRandomised controlled trialHumans
- Palmitoylethanolamide and polydatin in pediatric irritable bowel syndrome: A multicentric randomized controlled trialRandomised controlled trialHumansWith polydatin
- Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic NeuropathyRandomised controlled trialHumansWith superoxide dismutase, alpha lipoic acid, B vitamins, vitamin E, magnesium and zinc
- Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent painReviewHumansOther animals
- Ultramicronized Palmitoylethanolamide and Luteolin: Drug Candidates in Post-COVID-19 Critical Illness Neuropathy and Positioning-Related Peripheral Nerve Injury of the Upper ExtremityCase seriesHumansWith luteolin
- Extended Treatment with Micron-Size Oral Palmitoylethanolamide (PEA) in Chronic Pain: A Systematic Review and Meta-AnalysisMeta-analysisHumans
- The Comparative Efficacy of Palmitoylethanolamide (PEA) With the Combination of Pregabalin and Nortriptyline on Post-extraction Trigeminal Neuropathy by Using Magnetic Resonance (MR) Neurography: A Randomized Clinical TrialRandomised controlled trialHumansWith pregabalin and nortriptyline (a separate comparator arm, and also combined with palmitoylethanolamide in a third arm)
- A Fixed Combination of Palmitoylethanolamide and Melatonin (PEATONIDE) for the Management of Pain, Sleep, and Disability in Patients with Fibromyalgia: A Pilot StudyOpen-label, no control groupHumansWith melatonin
- A Brief Review on the Novel Therapies for Painful Diabetic NeuropathyReviewHumans
- Palmitoylethanolamide: A Potential Alternative to CannabidiolReviewHumans
- To Go Where Nature Leads: Focus on Palmitoylethanolamide and Related ALIAmides as Innovative Approach to Neuroinflammatory and Pain-Related Disease States in Honor of Doctor Francesco Della ValleReviewHumans
- A randomised controlled trial assessing the potential of palmitoylethanolamide (PEA) to act as an adjuvant to resistance training in healthy adults: a study protocolRandomised controlled trialHumans
- Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled TrialsMeta-analysisHumans
- Alpha-Lipoic Acid, Palmitoylethanolamide, Myrrh, and Oxygen-Ozone Therapy Improve Pharmacological Therapy in Acute Painful Lumbosacral Radiculopathy due to Herniated DiscObservational studyHumansWith alpha-lipoic acid and myrrh
- Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia: results of a randomised controlled studyRandomised controlled trialHumansWith acetyl-L-carnitine
- Orofacial Pain Management: An Overview of the Potential Benefits of Palmitoylethanolamide and Other Natural AgentsReviewHumans
- Exploring Outcome Priorities and Real-Life Management of Chemotherapy-Induced Peripheral Neurotoxicity: A Survey of the Italian Association for the Study of Pain membersObservational studyHumans
- Quantification of Analgesic and Anti-Inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic MembraneLaboratory studyHumans
- Oxygen-Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 PatientsObservational studyHumansWith alpha-lipoic acid and myrrh
- New Approach to Chronic Back Pain Treatment: A Case Control StudyControlled trialHumansWith alpha-lipoic acid and myrrh, with CT-guided periradicular oxygen-ozone injections
- Why Use Nutraceutical Strategies for the Irritable Bowel Syndrome?ReviewHumans
- Targeting Neuroinflammation in Osteoarthritis with Intra-Articular AdelmidrolReviewHumansOther animalsWith adelmidrol (a PEA analogue) with high molecular weight hyaluronic acid, by intra-articular injection
- Salivary Endocannabinoid Profiles in Chronic Orofacial Pain and Headache Disorders: An Observational Study Using a Novel Tool for Diagnosis and ManagementObservational studyHumans
- MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microgliaLaboratory studyOther animalsHumansWith luteolin (co-ultramicronised PEA plus luteolin, PEALut)
- Palmitoylethanolamide (PEA) in the treatment of neuropathic pain: a case studyCase seriesHumans
- Plasma and interstitial levels of endocannabinoids and N-acylethanolamines in patients with chronic widespread pain and fibromyalgia: a systematic review and meta-analysisMeta-analysisHumans
- The Effect of Palmitoylethanolamide on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers—A Randomized, Double-Blinded, Placebo-Controlled Crossover TrialRandomised controlled trialHumans
- Medical Cannabis for Gynecologic Pain Conditions: A Systematic ReviewReviewHumansWith Reviewed studies included PEA-combination medicines (partners not named in the abstract) alongside cannabis products
- Levels of bioactive endogenous lipids and health-related quality of life in Chronic Idiopathic Axonal PolyneuropathyObservational studyHumans
- Non-drug pain relievers active on non-opioid pain mechanismsReviewHumansOther animals
- Experience with nutraceutical supplements in the treatment of pelvic pain in gynaecology: case reportsCase seriesHumansWith alpha-lipoic acid and myrrh (a nutraceutical supplement), within a multimodal programme that also included hormone therapy, antineuropathic drugs, injections, behavioural and physical interventions
- Therapeutic Potential of Diacerein in Management of PainReviewHumansOther animals
- A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic painRandomised controlled trialHumans
- Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical EvidenceMeta-analysisHumans
- Investigating the Long-Term Effect of an Interdisciplinary Multimodal Rehabilitation Program on Levels of Bioactive Lipids and Telomerase Activity in Blood from Patients with Chronic PainOpen-label, no control groupHumans
- Long-term and serious harms of medical cannabis and cannabinoids for chronic pain: a systematic review of non-randomised studiesMeta-analysisHumans
- Effectiveness of Nonpharmacologic Treatments of Burning Mouth Syndrome: A Systematic ReviewReviewHumans
- Palmitoylethanolamide: A Natural Compound for Health ManagementReviewHumansOther animals
- Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trialRandomised controlled trialHumansWith baicalin
- Burning mouth syndrome: a review of therapeutic approachReviewHumans
- Efficacy of a fixed combination of palmitoylethanolamide and acetyl-l-carnitine (PEA+ALC FC) in the treatment of neuropathies secondary to rheumatic diseasesControlled trialHumansWith acetyl-L-carnitine 500 mg (fixed combination Kalanit, Chiesi)
- Improving Chemotherapy-Induced Peripheral Neuropathy in Patients with Breast or Colon Cancer after End of (Neo)adjuvant Therapy: Results from the Observational Study STEFANOObservational studyHumansWith a patented fatty acid mixture (OnLife)
- ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic PainReviewHumansOther animals
- Measuring the placebo effect in carpal tunnel syndromeRandomised controlled trialHumans
- ENDOCANNABINOIDS RECEPTORS MEDIATED CENTRAL AND PERIPHERAL EFFECTS (REVIEW)ReviewHumansOther animals
- Effect of intravenous, perioperative-administered lidocaine on serum levels of endocannabinoids and related N-acylethanolamines in childrenControlled trialHumans
- Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitorsLaboratory studyHumansOther animals
- Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries. A Systematic ReviewReviewHumans
- Combination of Rehabilitative Therapy with Ultramicronized Palmitoylethanolamide for Chronic Low Back Pain: An Observational StudyObservational studyHumans
- Increased Anandamide and Decreased Pain and Depression after Exercise in FibromyalgiaControlled trialHumans
- Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain functionOpen-label, no control groupHumans
- Add-on administration of ultramicronized palmitoylethanolamide in the treatment of new-onset burning mouth syndromeCase seriesHumans
- Micronized Palmitoylethanolamide: A Post Hoc Analysis of a Controlled Study in Patients with Low Back Pain – SciaticaRandomised controlled trialHumans
- The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic ReviewReviewHumans
- Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivityCase seriesHumans
- Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients: a preliminary randomized double-blind controlled trialRandomised controlled trialHumans
- Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in DietsReviewHumansOther animals
- Biomarkers of response to alpha-lipoic acid ± palmitoiletanolamide treatment in patients with diabetes and symptoms of peripheral neuropathyObservational studyHumansWith alpha-lipoic acid (all treated patients received it; PEA was added in some)
- Ultramicronized Palmitoylethanolamide (um-PEA) as Add-on Treatment in Fibromyalgia Syndrome (FMS): Retrospective Observational Study on 407 PatientsObservational studyHumans
- A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritisRandomised controlled trialHumans
- Altered relationship between anandamide and glutamate in circulation after 30 min of arm cycling: A comparison of chronic pain subject with healthy controlsControlled trialHumans
- Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide/polydatin on chronic pelvic pain and quality of life in endometriosis patients: An open-label pilot studyOpen-label, no control groupHumansWith polydatin
- Effects of Add-On Ultramicronized N-Palmitol Ethanol Amide in Patients Suffering of Migraine With Aura: A Pilot StudyControlled trialHumans
- Nonsurgical lumbar radiculopathies treated with ultramicronized palmitoylethanolamide (umPEA): A series of 100 casesCase seriesHumans
- Ultra-micronized Palmitoylethanolamide Effects on Sleep-wake Rhythm and Neuropathic Pain Phenotypes in Patients with Carpal Tunnel Syndrome: An Open-label, Randomized Controlled StudyControlled trialHumans
- Efficacy of Palmitoylethanolamide for Pain: A Meta-AnalysisMeta-analysisHumans
- Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndromeRandomised controlled trialHumansWith polydatin
- Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized studyRandomised controlled trialHumans
- N-of-1 Randomized Trials of Ultra-Micronized Palmitoylethanolamide in Older Patients with Chronic PainRandomised controlled trialHumans
- The efficacy of an association of palmitoylethanolamide and alpha-lipoic acid in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized clinical trialRandomised controlled trialHumansWith alpha-lipoic acid
- Palmitoylethanolamide in the Treatment of Failed Back Surgery SyndromeObservational studyHumansWith tapentadol and pregabalin
- The beneficial use of ultramicronized palmitoylethanolamide as add-on therapy to Tapentadol in the treatment of low back pain: a pilot study comparing prospective and retrospective observational armsObservational studyHumans
- Ultramicronized palmitoylethanolamide in spinal cord injury neuropathic pain: A randomized, double-blind, placebo-controlled trialRandomised controlled trialHumans
- Administration of palmitoylethanolamide in combination with topiramate in the preventive treatment of nummular headacheCase seriesHumansWith topiramate
- Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacyReviewHumans
- Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing–Remitting Multiple SclerosisRandomised controlled trialHumans
- Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysisMeta-analysisHumans
- Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational StudiesObservational studyHumans
- Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndromeReviewHumans
- Sex differences in N-palmitoylethanolamide effectiveness in neuropathic pain associated with lumbosciatalgiaControlled trialHumans
- Short-term efficacy of ultramicronized palmitoylethanolamide in peripheral neuropathic painOpen-label, no control groupHumans
- Effects of two different specific neck exercise interventions on palmitoylethanolamide and stearoylethanolamide concentrations in the interstitium of the trapezius muscle in women with chronic neck shoulder painRandomised controlled trialHumans
- Micronized Palmitoylethanolamide Reduces the Symptoms of Neuropathic Pain in Diabetic PatientsOpen-label, no control groupHumans
- Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different EtiopathogenesisObservational studyHumans
- Palmitoylethanolamide Versus a Nonsteroidal Anti-Inflammatory Drug in the Treatment of Temporomandibular Joint Inflammatory PainRandomised controlled trialHumans
- Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wristControlled trialHumans
- Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathyOpen-label, no control groupHumans
- Palmitoylethanolamide (Normast) in chronic neuropathic pain by compressive type lumbosciatalgia: multicentric clinical studyRandomised controlled trialHumans
- Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observationsCase seriesHumansWith polydatin
- Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgiaOpen-label, no control groupHumansTopical